KEGG   Homo sapiens (human): 8879
Entry
8879              CDS       T01001                                 
Symbol
SGPL1, NPHS14, RENI, S1PL, SPL
Name
(RefSeq) sphingosine-1-phosphate lyase 1
  KO
K01634  sphinganine-1-phosphate aldolase [EC:4.1.2.27]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00600  Sphingolipid metabolism
hsa01100  Metabolic pathways
hsa04071  Sphingolipid signaling pathway
Module
hsa_M00100  Sphingosine degradation
Disease
H01657  Nephrotic syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00600 Sphingolipid metabolism
    8879 (SGPL1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    8879 (SGPL1)
Enzymes [BR:hsa01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.27  sphinganine-1-phosphate aldolase
     8879 (SGPL1)
SSDB
Motif
Pfam: Pyridoxal_deC Aminotran_5 Aminotran_1_2 DegT_DnrJ_EryC1 SepSecS Cys_Met_Meta_PP
Other DBs
NCBI-GeneID: 8879
NCBI-ProteinID: NP_003892
OMIM: 603729
HGNC: 10817
Ensembl: ENSG00000166224
UniProt: O95470
Structure
Position
10:70815948..70881184
AA seq 568 aa
MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFV
FQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQG
LSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPG
LRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQS
AHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPE
VAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKG
SSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEAT
KQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFP
PSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAE
LSSVFLDSLYSTDTVTQGSQMNGSPKPH
NT seq 1707 nt   +upstreamnt  +downstreamnt
atgcctagcacagaccttctgatgttgaaggcctttgagccctacttagagattttggaa
gtatactccacaaaagccaagaattatgtaaatggacattgcaccaagtatgagccctgg
cagctaattgcatggagtgtcgtgtggaccctgctgatagtctggggatatgagtttgtc
ttccagccagagagtttatggtcaaggtttaaaaagaaatgttttaagctcaccaggaag
atgcccattattggtcgtaagattcaagacaagttgaacaagaccaaggatgatattagc
aagaacatgtcattcctgaaagtggacaaagagtatgtgaaagctttaccctcccagggt
ctgagctcatctgctgttttggagaaacttaaggagtacagctctatggacgccttctgg
caagaggggagagcctctggaacagtgtacagtggggaggagaagctcactgagctcctt
gtgaaggcttatggagattttgcatggagtaaccccctgcatccagatatcttcccagga
ctacgcaagatagaggcagaaatcgtgaggatagcttgttccctgttcaatgggggacca
gattcgtgtggatgtgtgacttctgggggaacagaaagcatactgatggcctgcaaagca
tatcgggatctggcctttgagaaggggatcaaaactccagaaattgtggctccccaaagt
gcccatgctgcatttaacaaagcagccagttactttgggatgaagattgtgcgggtccca
ttgacgaagatgatggaggtggatgtgcgggcaatgagaagagctatctccaggaacact
gccatgctcgtctgttctaccccacagtttcctcatggtgtaatagatcctgtccctgaa
gtggccaagctggctgtcaaatacaaaataccccttcatgtcgacgcttgtctgggaggc
ttcctcatcgtctttatggagaaagcaggatacccactggagcacccatttgatttccgg
gtgaaaggtgtaaccagcatttcagctgacacccataagtatggctatgccccaaaaggc
tcatcattggtgttgtatagtgacaagaagtacaggaactatcagttcttcgtcgataca
gattggcagggtggcatctatgcttccccaaccatcgcaggctcacggcctggtggcatt
agcgcagcctgttgggctgccttgatgcacttcggtgagaacggctatgttgaagctacc
aaacagatcatcaaaactgctcgcttcctcaagtcagaactggaaaatatcaaaggcatc
tttgtttttgggaatccccaattgtcagtcattgctctgggatcccgtgattttgacatc
taccgactatcaaacctgatgactgctaaggggtggaacttgaaccagttgcagttccca
cccagtattcatttctgcatcacattactacacgcccggaaacgagtagctatacaattc
ctaaaggacattcgagaatctgtcactcaaatcatgaagaatcctaaagcgaagaccaca
ggaatgggtgccatctatggcatggcccagacaactgttgacaggaatatggttgcagaa
ttgtcctcagtcttcttggacagcttgtacagcaccgacactgtcacccagggcagccag
atgaatggttctccaaaaccccactga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (15)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (37)   
   RefSeq(nuc) (13)   
   GenBank (12)   
   EMBL (12)   
3D Structure (2)   
   PDB (2)   
Protein domain (6)   
   Pfam (6)   
All databases (97)   

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